A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells

Abstract excerpt

Under certain instances, factor VIII (FVIII) stimulates an immune response, and the resulting neutralizing antibodies present a significant clinical challenge. Immunotherapies to re-establish or induce long-term tolerance would be beneficial, and an in-depth knowledge of mechanisms involved in tolerance induction is essential to develop immune-modulating strategies. We have developed a murine model system for...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Hemophilia Treatment and Research
• Share to Phagocytosis and Immune Regulation
• Share to Platelet Disorders and Treatments