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Article

MicroRNAs in the Human Heart

3 Jul 2007

Abstract excerpt

BACKGROUND: Chronic heart failure is characterized by left ventricular remodeling and reactivation of a fetal gene program; the underlying mechanisms are only partly understood. Here we provide evidence that cardiac microRNAs, recently discovered key regulators of gene expression, contribute to the transcriptional changes observed in heart failure. METHODS AND RESULTS: Cardiac transcriptome analyses revealed...

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Share to Cardiac Fibrosis and Remodeling
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Identifiers

PMID: 17606841
DOI: 10.1161/circulationaha.107.687947

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