Article
Characteristics associated with clinical severity and inflammatory phenotype of naturally occurring virus-induced exacerbations of asthma in adults.
Respiratory medicine - 1 Feb 2017
Bjerregaard Asger, Laing Ingrid A, Poulsen Nadia, Backer Vibeke, Sverrild Asger, Fally Markus, Khoo Siew-Kim, Barrett Lucy, Baltic Svetlana, Thompson Philip J, Chidlow Glenys, Sikazwe Chisha, Smith David W, Bochkov Yury A, Le Souëf Peter, Porsbjerg Celeste
Abstract excerpt
BACKGROUND: In experimental studies viral infections have been shown to induce type 2 inflammation in asthmatics, but whether this is a feature of naturally occurring virus-induced asthma exacerbations is unknown. Thymic stromal lymphopoietin (TSLP) released from the airway epithelium in response to damage, has been suggested as a link between viral infection and type 2 inflammation, but the role of TSLP in...
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