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DNA methylation and gene expression changes derived from assisted reproductive technologies can be decreased by reproductive fluids

30 Jan 2017

Abstract excerpt

The number of children born since the origin of Assisted Reproductive Technologies (ART) exceeds 5 million. The majority seem healthy, but a higher frequency of defects has been reported among ART-conceived infants, suggesting an epigenetic cost. We report the first whole-genome DNA methylation datasets from single pig blastocysts showing differences between in vivo and in vitro produced embryos. Blastocysts were...

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Share to Assisted Reproductive Technology and Twin Pregnancy
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PMID: 28134613
DOI: 10.7554/elife.23670

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