Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment.

doi:10.1038/srep41660

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Article

Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment.

Scientific reports - 30 Jan 2017

Kai Yugo, Hikita Hayato, Morishita Naoki, Murai Kazuhiro, Nakabori Tasuku, Iio Sadaharu, Hagiwara Hideki, Imai Yasuharu, Tamura Shinji, Tsutsui Syusaku, Naito Masafumi, Nishiuchi Meiko, Kondo Yasuteru, Kato Takanobu, Suemizu Hiroshi, Yamada Ryoko, Oze Tsugiko, Yakushijin Takayuki, Hiramatsu Naoki, Sakamori Ryotaro, Tatsumi Tomohide, Takehara Tetsuo

Abstract excerpt

Resistance-associated substitutions (RASs) in hepatitis C virus (HCV) appear upon failure of treatment with direct-acting antivirals (DAAs). However, their origin has not been clarified in detail. Among 11 HCV genotype 1b patients who experienced virologic failure with asunaprevir (ASV)/daclatasvir (DCV), 10 had major NS5A L31M/V-Y93H variants after treatment. L31M/V-Y93H variants were detected as a minor clone...

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PMID: 28134353
DOI: 10.1038/srep41660
PMCID: PMC5278351

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