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Article

Interferon-inducible LY6E Protein Promotes HIV-1 Infection.

The Journal of biological chemistry - 17 Mar 2017

Yu Jingyou, Liang Chen, Liu Shan-Lu

Abstract excerpt

LY6E is a glycosylphosphatidylinositol-anchored, IFN-inducible protein that regulates T lymphocytes proliferation, differentiation, and development. Single-nucleotide polymorphism rs2572886 in the LY6 family protein locus has been shown to associate with accelerated progression to AIDS. In this study, we show that LY6E promotes HIV, type 1 (HIV-1) infection by enhancing viral entry and gene expression. Knockdown...

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Topics

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Share to Antigens, Surface
Share to Gene Expression Regulation, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Knockdown Techniques

Share to GPI-Linked Proteins

Share to HIV Long Terminal Repeat

Share to Interferons

Share to Leukocytes, Mononuclear

Share to Virus Internalization

Source

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Identifiers

PMID: 28130445
DOI: 10.1074/jbc.M116.755819
PMCID: PMC5377782

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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