Article
A functional variant in ST2 gene is associated with risk of hypertension via interfering MiR-202-3p.
Journal of cellular and molecular medicine - 1 Jul 2017
Wu Fangqin, Li Lu, Wen Qiang, Yang Jinhua, Chen Zhuyue, Wu Peng, He Meian, Zhang Xiaomin, Wu Tangchun, Cheng Longxian
Abstract excerpt
Recent studies have suggested that interleukin 1 receptor-like 1 (ST2) plays a critical role in pathogenesis of several cardiovascular disease conditions. In this study, we examined association of 13 single nucleotide polymorphisms (SNPs) of ST2 gene with essential hypertension (EH) risk in 1151 patients with EH and 1135 controls. Our study showed that variants rs11685424, rs12999364 and rs3821204 are highly...
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