Article
Mutations near the cleavage site of enterocin NKR-5-3B prepeptide reveal new insights into its biosynthesis.
Microbiology (Reading, England) - 1 Apr 2017
Perez Rodney H, Sugino Haruki, Ishibashi Naoki, Zendo Takeshi, Wilaipun Pongtep, Leelawatcharamas Vichien, Nakayama Jiro, Sonomoto Kenji
Abstract excerpt
Enterocin NKR-5-3B (Ent53B) is a 64-residue novel circular bacteriocin synthesized from an 87-residue prepeptide. Albeit through a still unknown mechanism, the EnkB1234 biosynthetic enzyme complex processes the prepeptide to yield its mature active, circular form. To gain insights into the key region/residue that plays a role in Ent53 maturation, several mutations near the cleavage site on the precursor peptide...
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