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Article

Glycine Substitutions in Collagen Heterotrimers Alter Triple Helical Assembly.

Biomacromolecules - 13 Feb 2017

Clements Katherine A, Acevedo-Jake Amanda M, Walker Douglas R, Hartgerink Jeffrey D

Abstract excerpt

Osteogenesis imperfecta typically results from missense mutations in the collagen genome where the required glycine residues are replaced with another amino acid. Many models have attempted to replicate the structure of mutated collagen on the triple helix level. However, composition and register control of the triple helix is complicated and requires extreme precision, especially when these destabilizing...

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Identifiers

PMID: 28098982
DOI: 10.1021/acs.biomac.6b01808

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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