Article

Local sequence context determines the effect of glycine substitutions in collagen triple helices

2026-06-04

Abstract excerpt

Glycine substitutions in the collagen triple helix cause diverse heritable disorders, but their effects vary with local sequence environment. We tested whether sequence context helps determine the consequences of Gly replacement by combining case-weighted bioinformatic analysis, thermodynamic measurements on collagen model peptides (CMPs), and all-atom molecular dynamics simulations. Case-weighted analysis of path...

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Literature Corpus work: 697b1fa8-6692-5dff-9bad-695a2ec5246e
DOI: 10.64898/2026.06.01.729402

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