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Article

Lysine Decarboxylase with an Enhanced Affinity for Pyridoxal 5-Phosphate by Disulfide Bond-Mediated Spatial Reconstitution.

PloS one - 1 Jan 2017

Sagong Hye-Young, Kim Kyung-Jin

Abstract excerpt

Lysine decarboxylase (LDC) catalyzes the decarboxylation of l-lysine to produce cadaverine, an important industrial platform chemical for bio-based polyamides. However, due to high flexibility at the pyridoxal 5-phosphate (PLP) binding site, use of the enzyme for cadaverine production requires continuous supplement of large amounts of PLP. In order to develop an LDC enzyme from Selenomonas ruminantium (SrLDC)...

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Identifiers

PMID: 28095457
DOI: 10.1371/journal.pone.0170163
PMCID: PMC5240995

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Source receipt: pubmed, retrieved 7 Sept 2026.

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