Article
Potential of gene drives with genome editing to increase genetic gain in livestock breeding programs.
Genetics, selection, evolution : GSE - 4 Jan 2017
Gonen Serap, Jenko Janez, Gorjanc Gregor, Mileham Alan J, Whitelaw C Bruce A, Hickey John M
Abstract excerpt
BACKGROUND: This paper uses simulation to explore how gene drives can increase genetic gain in livestock breeding programs. Gene drives are naturally occurring phenomena that cause a mutation on one chromosome to copy itself onto its homologous chromosome. METHODS: We simulated nine different breeding and editing scenarios with a common overall structure. Each scenario began with 21 generations of selection,...
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