Article
Choline acetyltransferase may contribute to the risk of Tourette syndrome: Combination of family-based analysis and case-control study.
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Oct 2018
Yang Xiuling, Liu Wenmiao, Yi Mingji, Zhang Ru, Xu Yinglei, Huang Zuzhou, Liu Shiguo, Li Tang
Abstract excerpt
OBJECTIVES: Twin and family analyses have revealed a genetic contribution to Tourette syndrome (TS) and post-mortem studies have raised the intriguing possibility of a reduction in cholinergic interneuronsin TS patients. METHODS: We selected five tag SNPs (rs100824791, rs12264845, rs1880676, rs3793790 and rs3793798) of choline acetyltransferase (CHAT) from the Han Chinese population Hapmap database. Genotyping...