The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1.

doi:10.1016/j.vaccine.2016.12.037

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Article

The global distribution and diversity of protein vaccine candidate antigens in the highly virulent Streptococcus pnuemoniae serotype 1.

Vaccine - 7 Feb 2017

Cornick Jennifer E, Tastan Bishop Özlem, Yalcin Feyruz, Kiran Anmol M, Kumwenda Benjamin, Chaguza Chrispin, Govindpershad Shanil, Ousmane Sani, Senghore Madikay, du Plessis Mignon, Pluschke Gerd, Ebruke Chinelo, McGee Lesley, Sigaùque Beutel, Collard Jean-Marc, Bentley Stephen D, Kadioglu Aras, Antonio Martin, von Gottberg Anne, French Neil, Klugman Keith P, Heyderman Robert S, Alderson Mark, Everett Dean B

Abstract excerpt

Serotype 1 is one of the most common causes of pneumococcal disease worldwide. Pneumococcal protein vaccines are currently being developed as an alternate intervention strategy to pneumococcal conjugate vaccines. Pre-requisites for an efficacious pneumococcal protein vaccine are universal presence and minimal variation of the target antigen in the pneumococcal population, and the capability to induce a robust...

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PMID: 28081968
DOI: 10.1016/j.vaccine.2016.12.037
PMCID: PMC5287219

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