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Purification of Zika virus RNA-dependent RNA polymerase and its use to identify small-molecule Zika inhibitors

3 Nov 2016

Abstract excerpt

Background: The viral RNA-dependent RNA polymerase (RdRp) enzymes of the Flaviviridae family are essential for viral replication and are logically important targets for development of antiviral therapeutic agents. Zika virus (ZIKV) is a rapidly re-emerging human pathogen for which no vaccine or antiviral agent is currently available. Methods: To facilitate development of ZIKV RdRp inhibitors, we have established...

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PMID: 28069884
DOI: 10.1093/jac/dkw514

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