Article
A novel role for the DNA repair gene Rad51 in Netrin-1 signalling.
Scientific reports - 6 Jan 2017
Glendining K A, Markie D, Gardner R J M, Franz E A, Robertson S P, Jasoni C L
Abstract excerpt
Mutations in RAD51 have recently been linked to human Congenital Mirror Movements (CMM), a developmental disorder of the motor system. The only gene previously linked to CMM encodes the Netrin-1 receptor DCC, which is important for formation of corticospinal and callosal axon tracts. Thus, we hypothesised that Rad51 has a novel role in Netrin-1-mediated axon development. In mouse primary motor cortex neurons,...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.