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Article

Cocapture of cognate and bystander antigens can activate autoreactive B cells

5 Jan 2017

Abstract excerpt

Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with autoimmune central nervous system diseases like acute disseminated encephalomyelitis (ADEM). For ADEM, it is speculated that a preceding infection is the trigger of the autoimmune response, but the mechanism connecting the infection to the production of MOG antibodies remains a mystery. We reasoned that the ability of B cells to...

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PMID: 28057865
DOI: 10.1073/pnas.1614472114

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