Article
Biomechanical CT metrics are associated with patient outcomes in COPD.
Thorax - 1 May 2017
Bodduluri Sandeep, Bhatt Surya P, Hoffman Eric A, Newell John D, Martinez Carlos H, Dransfield Mark T, Han Meilan K, Reinhardt Joseph M
Abstract excerpt
BACKGROUND: Traditional metrics of lung disease such as those derived from spirometry and static single-volume CT images are used to explain respiratory morbidity in patients with COPD, but are insufficient. We hypothesised that the mean Jacobian determinant, a measure of local lung expansion and contraction with respiration, would contribute independently to clinically relevant functional outcomes. METHODS: We...
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