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Article

CD54-NOTCH1 axis controls tumor initiation and cancer stem cell functions in human prostate cancer

10 Nov 2016

Abstract excerpt

Cancer stem cells (CSCs) are considered one of the key contributors to chemoresistance and tumor recurrence. Therefore, the precise identification of reliable CSC markers and clarification of the intracellular signaling involved in CSCs remains a great challenge in fields relating to cancer biology. Here, we implemented a novel chemoresistant prostate cancer patient-derived xenograft (PDX) model in NOD/SCID mice...

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PMID: 28042317
DOI: 10.7150/thno.16752

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