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Article

High-throughput pharmacogenetics identifies SLCO1A2 polymorphisms as candidates to elucidate the risk of febrile neutropenia in the breast cancer RAPP-01 trial.

Breast cancer research and treatment - 1 Sept 2015

Callens Céline, Debled Marc, Delord Marc, Turbiez-Stalain Isabelle, Veyret Corinne, Bièche Ivan, Brain Etienne

Abstract excerpt

The RAPP-01 clinical trial compared two adjuvant chemotherapies, doxorubicin plus docetaxel (arm A) versus doxorubicin plus cyclophosphamide (arm B), in 627 women with breast cancer. It stopped prematurely when three severe adverse events occurred among patients with febrile neutropenia (FN), all in the arm A. FN occurred in 40.8% (126/311) in arm A versus 7.1% (22/316) in arm B. We investigated Single Nucleotide...

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PMID: 26318989
DOI: 10.1007/s10549-015-3552-7

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