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Article

Mobile genetic elements mediating antimicrobial resistance drive the evolutionary process of Clostridioides difficile ST37/RT017.

BMC genomics - 12 Jul 2025

Lv Tao, Bi Xiajing, Zheng Lisi, Zhao Yuhong, Zhou Yizheng, Wu Tao, Shen Ping, Zhu Danhua, Chen Shiyao, Chen Yunbo

Abstract excerpt

BACKGROUND: Clostridioides difficile (C. difficile) ST37/RT017 is one of the most prevalent genotypes, exhibiting resistance to multiple antimicrobial agents and widespread dissemination, particularly in East Asia. However, its evolutionary history and genetic adaptation remains limited. Here, we aimed to systematically assess the genetic diversity, key evolutionary events, and potential driving forces of C....

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Identifiers

PMID: 40652164
DOI: 10.1186/s12864-025-11822-4
PMCID: PMC12255112

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