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Article

Dysregulation of mitophagy in carcinogenesis and tumor progression.

Biochimica et biophysica acta. Bioenergetics - 1 Aug 2017

Chang Joon Young, Yi Hyon-Seung, Kim Hyeon-Woo, Shong Minho

Abstract excerpt

The mitochondrial role in carcinogenesis and cancer progression is an area of active research, with many unresolved questions. Various aspects of altered mitochondrial function have been implicated in tumorigenesis and tumor progression, including mitochondrial dysfunction, a metabolic switch to aerobic glycolysis, and dysregulation of mitophagy. Mitophagy is a highly specific quality control process which...

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PMID: 28017650
DOI: 10.1016/j.bbabio.2016.12.008

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