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Article

Efferocytosis is impaired in Gaucher macrophages.

Haematologica - 1 Apr 2017

Aflaki Elma, Borger Daniel K, Grey Richard J, Kirby Martha, Anderson Stacie, Lopez Grisel, Sidransky Ellen

Abstract excerpt

Gaucher disease, the inherited deficiency of lysosomal glucocerebrosidase, is characterized by the presence of glucosylceramide-laden macrophages resulting from impaired digestion of aged erythrocytes or apoptotic leukocytes. Studies of macrophages from patients with type 1 Gaucher disease with genotypes N370S/N370S, N370S/L444P or N370S/c.84dupG revealed that Gaucher macrophages have impaired efferocytosis...

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Identifiers

PMID: 28011901
DOI: 10.3324/haematol.2016.155093
PMCID: PMC5395106

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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