Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired autophagosomes and lysosomes in neuronopathic Gaucher disease.

Autophagy - 1 Jul 2010

Sun Ying, Grabowski Gregory A

Abstract excerpt

Gaucher disease is an inherited autosomal recessive disease caused by mutations of acid β-glucosidase, a lysosomal hydrolase specific for degradation of glucosylceramide and glucosylsphingosine in the glycosphingolipid metabolic pathway. Clinically, Gaucher disease is classified into three types:...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Brain
Share to Disease Models, Animal
Share to Gaucher Disease

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lysosomes

Share to Nerve Degeneration

Share to Neurons

Share to Phagosomes

Source

Identifiers

PMID: 20458183
DOI: 10.4161/auto.6.5.12047

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20458183-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired autophagosomes and lysosomes in neuronopathic Gaucher disease.PMID 20458183Read ↗

Gaucher disease: a lysosomal neurodegenerative disorder.Semantic proximity Read ↗

Dysregulation of the autophagic-lysosomal pathway in Gaucher and Parkinson's diseaseSemantic proximity Read ↗

Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits.Semantic proximity Read ↗

Animal Models for the Study of Gaucher Disease.Semantic proximity Read ↗

Defective quality control mechanisms and accumulation of damaged mitochondria link Gaucher and Parkinson diseasesSemantic proximity Read ↗

Lysosomal functions and dysfunctions: Molecular and cellular mechanisms underlying Gaucher disease and its association with Parkinson disease.Semantic proximity Read ↗

Murine models of acute neuronopathic Gaucher diseaseSemantic proximity Read ↗

New Directions in Gaucher Disease.Semantic proximity Read ↗

Neuronal forms of Gaucher disease.Semantic proximity Read ↗

Altered expression and distribution of cathepsins in neuronopathic forms of Gaucher disease and in other sphingolipidosesSemantic proximity Read ↗

A Comparative Biochemical and Pathological Evaluation of Brain Samples from Knock-in Murine Models of Gaucher DiseaseSemantic proximity Read ↗

Glucocerebrosidase is shaking up the synucleinopathies.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.