Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitis

23 Dec 2016

Abstract excerpt

We read the recent publication of Schnúr et al. [1] with great interest, in which the authors proposed that a subset of human cationic trypsinogen (PRSS1) variants cause chronic pancreatitis by inducing misfolding and endoplasmic reticulum (ER) stress rather than increased intra-pancreatic trypsin activity.PRSS1 variants that promote premature trypsinogen activation are the strongest known risk factors for...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Gastrointestinal disorders and treatments
Share to Pancreatic and Hepatic Oncology Research
Share to Pancreatitis Pathology and Treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28011893
DOI: 10.1136/gutjnl-2016-313451

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitisPMID 28011893Read ↗

Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis.Semantic proximity Read ↗

Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitisSemantic proximity Read ↗

Misfolding PRSS1 variant p.Ala61Val in a case of suspected intrauterine pancreatitis.Semantic proximity Read ↗

Hereditary pancreatitis caused by mutation-induced misfolding of human cationic trypsinogen: a novel disease mechanism.Semantic proximity Read ↗

Genetic risk in chronic pancreatitis: the misfolding-dependent pathway.Semantic proximity Read ↗

Functional effects of 13 rare PRSS1 variants presumed to cause chronic pancreatitis.Semantic proximity Read ↗

Cationic trypsinogen mutations and pancreatitis.Semantic proximity Read ↗

Cationic trypsinogen mutations and pancreatitis.Semantic proximity Read ↗

<i>SPINK1</i> mutations and phenotypic expression in patients with pancreatitis associated with trypsinogen mutationsSemantic proximity Read ↗

Mutations of the cationic trypsinogen in hereditary pancreatitis.Semantic proximity Read ↗

Mutations in serine protease inhibitor Kazal type 1 are strongly associated with chronic pancreatitis.Semantic proximity Read ↗

A novel mutation of the calcium sensing receptor gene is associated with chronic pancreatitis in a family with heterozygous SPINK1 mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.