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Article

Recognition of c9orf72 Mutant RNA by Single-Stranded Silencing RNAs.

Nucleic acid therapeutics - 1 Apr 2017

Hu Jiaxin, Rigo Frank, Prakash Thazha P, Corey David R

Abstract excerpt

Mutations within the chromosome 9 open reading frame 72 (c9orf72) gene are associated with both familial amyotrophic lateral sclerosis and frontotemporal dementia. The mutation leads to an expanded GGGGCC hexanucleotide repeat within the first intron of c9orf72 and an expanded CCCCGG repeat within a corresponding antisense transcript. Both the mutant intronic and antisense RNAs have been implicated in disease. We...

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Share to Amyotrophic Lateral Sclerosis
Share to C9orf72 Protein
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oligonucleotides, Antisense

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Source

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Identifiers

PMID: 28005462
DOI: 10.1089/nat.2016.0655
PMCID: PMC5372765

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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