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Article

Structural basis of the substrate preference towards CMP for a thymidylate synthase MilA involved in mildiomycin biosynthesis.

Scientific reports - 21 Dec 2016

Zhao Gong, Chen Cheng, Xiong Wei, Gao Tuling, Deng Zixin, Wu Geng, He Xinyi

Abstract excerpt

Modified pyrimidine monophosphates such as methyl dCMP (mdCMP), hydroxymethyl dUMP (hmdUMP) and hmdCMP in some phages are synthesized by a large group of enzymes termed as thymidylate synthases (TS). Thymidylate is a nucleotide required for DNA synthesis and thus TS is an important drug target. In the biosynthetic pathway of the nucleoside fungicide mildiomycin isolated from Streptomyces rimofaciens ZJU5119, a...

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Identifiers

PMID: 28000775
DOI: 10.1038/srep39675
PMCID: PMC5175136

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Source receipt: pubmed, retrieved 7 Sept 2026.

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