Article
The targetable A1 Huntington disease haplotype has distinct Amerindian and European origins in Latin America.
European journal of human genetics : EJHG - 1 Feb 2017
Kay Chris, Tirado-Hurtado Indira, Cornejo-Olivas Mario, Collins Jennifer A, Wright Galen, Inca-Martinez Miguel, Veliz-Otani Diego, Ketelaar Maria E, Slama Ramy A, Ross Colin J, Mazzetti Pilar, Hayden Michael R
Abstract excerpt
Huntington disease (HD) is a dominant neurodegenerative disorder caused by a CAG repeat expansion in the Huntingtin (HTT) gene. HD occurs worldwide, but the causative mutation is found on different HTT haplotypes in distinct ethnic groups. In Latin America, HD is thought to have European origins, but indigenous Amerindian ancestry has not been investigated. Here, we report dense HTT haplotypes in 62 mestizo...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.