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Article

Tertiary Epimutations - A Novel Aspect of Epigenetic Transgenerational Inheritance Promoting Genome Instability.

PloS one - 1 Jan 2016

McCarrey John R, Lehle Jake D, Raju Seetha S, Wang Yufeng, Nilsson Eric E, Skinner Michael K

Abstract excerpt

Exposure to environmental factors can induce the epigenetic transgenerational inheritance of disease. Alterations to the epigenome termed "epimutations" include "primary epimutations" which are epigenetic alterations in the absence of genetic change and "secondary epimutations" which form following an initial genetic change. To determine if secondary epimutations contribute to transgenerational transmission of...

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Identifiers

PMID: 27992467
DOI: 10.1371/journal.pone.0168038
PMCID: PMC5167269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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