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Efficient generation of B2m-null pigs via injection of zygote with TALENs

16 Dec 2016

Abstract excerpt

Donor major histocompatibility complex class I (MHC I) molecules are the main targets of the host immune response after organ allotransplantation. Whether and how MHC I-deficiency of pig donor tissues affects rejection after xenotransplantation has not been assessed. Beta2-microglobulin (B2M) is indispensable for the assembly of MHC I receptors and therefore provides an effective target to disrupt cell surface...

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PMID: 27982048
DOI: 10.1038/srep38854

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