Article
PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
Science translational medicine - 14 Dec 2016
Anderson Gray R, Wardell Suzanne E, Cakir Merve, Crawford Lorin, Leeds Jim C, Nussbaum Daniel P, Shankar Pallavi S, Soderquist Ryan S, Stein Elizabeth M, Tingley Jennifer P, Winter Peter S, Zieser-Misenheimer Elizabeth K, Alley Holly M, Yllanes Alexander, Haney Victoria, Blackwell Kimberly L, McCall Shannon J, McDonnell Donald P, Wood Kris C
Abstract excerpt
Therapies that efficiently induce apoptosis are likely to be required for durable clinical responses in patients with solid tumors. Using a pharmacological screening approach, we discovered that combined inhibition of B cell lymphoma-extra large (BCL-XL) and the mammalian target of rapamycin (mTOR)/4E-BP axis results in selective and synergistic induction of apoptosis in cellular and animal models of PIK3CA...
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