Article
A Comparison and Integration of MiSeq and MinION Platforms for Sequencing Single Source and Mixed Mitochondrial Genomes.
PloS one - 1 Jan 2016
Lindberg Michael R, Schmedes Sarah E, Hewitt F Curtis, Haas Jamie L, Ternus Krista L, Kadavy Dana R, Budowle Bruce
Abstract excerpt
Single source and multiple donor (mixed) samples of human mitochondrial DNA were analyzed and compared using the MinION and the MiSeq platforms. A generalized variant detection strategy was employed to provide a cursory framework for evaluating the reliability and accuracy of mitochondrial sequences produced by the MinION. The feasibility of long-read phasing was investigated to establish its efficacy in...
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