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Article

Generation of human embryonic stem cells from abnormal blastocyst diagnosed with adrenoleukodystrophy.

Stem cell research - 1 Nov 2016

Ouyang Qi, Zhou Xiaoying, Chen Jing, Du Juan, Lu Guangxiu, Lin Ge, Sun Yi

Abstract excerpt

Human embryonic stem cell (hESC) line chHES-480 was derived from abnormal blastocyst diagnosed with adrenoleukodystrophy (ALD) after preimplantation genetic diagnosis (PGD) treatment. DNA sequencing analysis confirmed that chHES-480 cell line carried a hemizygous missense mutation c.1825G>A(p.Glu609Lys) of ABCD1 gene. Characteristic tests proved that the chHES-480 cell line presented typical markers of...

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Source

Identifiers

PMID: 27934597
DOI: 10.1016/j.scr.2016.11.003

Genes

ABCD1
PGD

Variants

Provenance

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Generation of human embryonic stem cells from abnormal blastocyst diagnosed with adrenoleukodystrophy.PMID 27934597Read ↗

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