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Article

TIS21/BTG2 inhibits doxorubicin-induced stress fiber-vimentin networks via Nox4-ROS-ABI2-DRF-linked signal cascade.

Cellular signalling - 1 Jan 2017

Lim In Kyoung, Choi Jung-A, Kim Eun Young, Kim Bit Na, Jang Soohyun, Ryu Min Sook, Shim Sang-Hee

Abstract excerpt

Activities of TIS21/BTG2 gene regulating cancer cell senescence were investigated in hepatoma cells by using low dose doxorubicin (Doxo, 100ng/mL). Treatment of Huh7 cells with Doxo increased linear actin nucleation e.g., transverse arcs and ventral stress fibers, as opposed to loss of filopodia. The linear actin nucleation was accompanied with thick vimentin networks at periphery of the cells, when examined by...

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Source

Identifiers

PMID: 27932314
DOI: 10.1016/j.cellsig.2016.12.001

Genes

ABI2
BTG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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