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Article

microRNA-27a rs895819 is associated with obesity in HIV infected preeclamptic Black South African women on HAART.

BMC medical genetics - 5 Dec 2016

Maharaj Niren Ray, Ramkaran Prithiksha, Pillay Siddharthiya, Chuturgoon Anil Amichund

Abstract excerpt

BACKGROUND: Preeclampsia (PE) and HIV/AIDS present a major health challenge globally. South Africa has the highest disease burden of both HIV/AIDS and PE in the world. Despite extensive research, the pathophysiology of these conditions is not completely understood, however a genetic predisposition in women may affect susceptibility. MiRNA-27a regulates adipogenesis and glucose metabolism. A single nucleotide...

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Pregnancy
Anti-HIV Agents
Antiretroviral Therapy, Highly Active
Body Mass Index
HIV Infections

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PMID: 27919232
DOI: 10.1186/s12881-016-0353-8
PMCID: PMC5139039

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