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Prevalence and clinical significance of BRCA1/2 germline and somatic mutations in Taiwanese patients with ovarian cancer.

Oncotarget - 20 Dec 2016

Chao Angel, Chang Ting-Chang, Lapke Nina, Jung Shih-Ming, Chi Peter, Chen Chien-Hung, Yang Lan-Yan, Lin Cheng-Tao, Huang Huei-Jean, Chou Hung-Hsueh, Liou Jui-Der, Chen Shu-Jen, Wang Tzu-Hao, Lai Chyong-Huey

Abstract excerpt

Germline and somatic BRCA1/2 mutations define a subset of patients with ovarian cancer who may benefit from treatment with poly (ADP-ribose) polymerase inhibitors. Unfortunately, data on the frequency of BRCA1/2 germline mutations in Taiwanese patients with ovarian cancer are scarce, with the prevalence of somatic mutations being unknown. We aim to investigate the occurrence of BRCA1/2 mutations in 99 Taiwanese...

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Identifiers

PMID: 27907908
DOI: 10.18632/oncotarget.13456
PMCID: PMC5356755

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BRCA1
BRCA2

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