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Article

Peroxiredoxin 2 is essential for maintaining cancer stem cell-like phenotype through activation of Hedgehog signaling pathway in colon cancer.

Oncotarget - 27 Dec 2016

Wang Rong, Wei Jinlai, Zhang Shouru, Wu Xingye, Guo Jinbao, Liu Maoxi, Du Kunli, Xu Jun, Peng Linglong, Lv Zhenbing, You Wenxian, Xiong Yongfu, Fu Zhongxue

Abstract excerpt

Cancer stem cells (CSCs) are a key target for reducing tumor growth, metastasis, and recurrence. Redox status is a critical factor in the maintenance of CSCs, and the antioxidant enzyme Peroxiredoxin 2 (Prdx2) plays an important role in the development of colon cancer. Therefore, we investigated the contribution of Prdx2 to the maintenance of stemness of colon CSCs. Here, we used short-hairpin RNAs and a...

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Identifiers

PMID: 27894099
DOI: 10.18632/oncotarget.13559
PMCID: PMC5349956

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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