Article
A combined linkage and association strategy identifies a variant near the GSTP1 gene associated with BMI in the Mexican population.
Journal of human genetics - 1 Mar 2017
Villamil-Ramírez Hugo, León-Mimila Paola, Macias-Kauffer Luis R, Canizalez-Román Adrián, Villalobos-Comparán Marisela, León-Sicairos Nidia, Vega-Badillo Joel, Sánchez-Muñoz Fausto, López-Contreras Blanca, Morán-Ramos Sofía, Villarreal-Molina Teresa, Zurita Luis C, Campos-Pérez Francisco, Huertas-Vazquez Adriana, Bojalil Rafael, Romero-Hidalgo Sandra, Aguilar-Salinas Carlos A, Canizales-Quinteros Samuel
Abstract excerpt
Obesity is a major public health concern in Mexico and worldwide. Although the estimated heritability is high, common variants identified by genome-wide association studies explain only a small proportion of this heritability. A combination of linkage and association strategies could be a more robust and powerful approach to identify other obesity-susceptibility variants. We thus sought to identify novel genetic...
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