Article
APOEε4 impacts up-regulation of brain-derived neurotrophic factor after a six-month stretch and aerobic exercise intervention in mild cognitively impaired elderly African Americans: A pilot study.
Experimental gerontology - 1 Jan 2017
Allard Joanne S, Ntekim Oyonumo, Johnson Steven P, Ngwa Julius S, Bond Vernon, Pinder Dynell, Gillum Richard F, Fungwe Thomas V, Kwagyan John, Obisesan Thomas O
Abstract excerpt
Possession of the Apolipoprotein E (APOE) gene ε4 allele is the most prevalent genetic risk factor for late onset Alzheimer's disease (AD). Recent evidence suggests that APOE genotype differentially affects the expression of brain-derived neurotrophic factor (BDNF). Notably, aerobic exercise-induced upregulation of BDNF is well documented; and exercise has been shown to improve cognitive function. As BDNF is...
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