Article
A genetic variant in GLP1R is associated with response to DPP-4 inhibitors in patients with type 2 diabetes.
Medicine - 1 Nov 2016
Han Eugene, Park Hye Sun, Kwon Obin, Choe Eun Yeong, Wang Hye Jin, Lee Yong-Ho, Lee Sang-Hak, Kim Chul Hoon, Kim Lee-Kyung, Kwak Soo Heon, Park Kyong Soo, Kim Chul Sik, Kang Eun Seok
Abstract excerpt
Incretin hormone-based therapy in type 2 diabetes has been widely used, and dipepdityl peptidase-4 (DPP-4) inhibitors, which prevent incretin degradation, have become popular oral hypoglycemic agents. The efficacy of DPP-4 inhibitors varies from individuals, and factors determining responses to DPP-4 inhibitors have not been fully established. We aimed to investigate whether genetic variations in glucagon-like...
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