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Mammalian Cell-Free System Recapitulates the Early Events of Post-Fertilization Sperm Mitophagy

17 Sept 2021

Abstract excerpt

Propagation of paternal sperm-contributed mitochondrial genes, resulting in heteroplasmy, is seldom observed in mammals due to post-fertilization degradation of sperm mitochondria, referred to as sperm mitophagy. Whole organelle sperm mitochondrion degradation is thought to be mediated by the interplay between the ubiquitin-proteasome system (UPS) and the autophagic pathway (Song et al., Proc. Natl. Acad. Sci....

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PMID: 34572103
DOI: 10.3390/cells10092450

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