Article
Systematic Analysis of Cell-to-Cell Expression Variation of T Lymphocytes in a Human Cohort Identifies Aging and Genetic Associations.
Immunity - 15 Nov 2016
Lu Yong, Biancotto Angelique, Cheung Foo, Remmers Elaine, Shah Naisha, McCoy J Philip, Tsang John S
Abstract excerpt
Cell-to-cell expression variation (CEV) is a prevalent feature of even well-defined cell populations, but its functions, particularly at the organismal level, are not well understood. Using single-cell data obtained via high-dimensional flow cytometry of T cells as a model, we introduce an analysis framework for quantifying CEV in primary cell populations and studying its functional associations in human cohorts....
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