Article
Pulmonary Vasculopathy Associated with FIGF Gene Mutation.
The American journal of pathology - 1 Jan 2017
Bailey Evan, Cui Ye, Casey Alicia, Stoler Joan M, Ai Xingbin, Ma Dongdong, Handin Robert, Sliz Piotr, Vargas Sara O, El-Chemaly Souheil Y
Abstract excerpt
Vascular endothelial growth factor (VEGF)-D is capable of inducing angiogenesis and lymphangiogenesis through signaling via VEGF receptor (VEGFR)-2 and VEGFR-3, respectively. Mutations in the FIGF (c-fos-induced growth factor) gene encoding VEGF-D have not been reported previously. We describe a young male with a hemizygous mutation in the X-chromosome gene FIGF (c.352 G>A) associated with early childhood...
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