Article
Mutational activation of BRAF confers sensitivity to transforming growth factor beta inhibitors in human cancer cells.
Oncotarget - 13 Dec 2016
Spender Lindsay C, Ferguson G John, Liu Sijia, Cui Chao, Girotti Maria Romina, Sibbet Gary, Higgs Ellen B, Shuttleworth Morven K, Hamilton Tom, Lorigan Paul, Weller Michael, Vincent David F, Sansom Owen J, Frame Margaret, Dijke Peter Ten, Marais Richard, Inman Gareth J
Abstract excerpt
Recent data implicate elevated transforming growth factor-β (TGFβ) signalling in BRAF inhibitor drug-resistance mechanisms, but the potential for targeting TGFβ signalling in cases of advanced melanoma has not been investigated. We show that mutant BRAFV600E confers an intrinsic dependence on TGFβ/TGFβ receptor 1 (TGFBR1) signalling for clonogenicity of murine melanocytes. Pharmacological inhibition of the TGFBR1...
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