Article
Pubertal and adult windows of susceptibility to a high animal fat diet in Trp53-null mammary tumorigenesis.
Oncotarget - 13 Dec 2016
Zhu Yirong, Aupperlee Mark D, Zhao Yong, Tan Ying Siow, Kirk Erin L, Sun Xuezheng, Troester Melissa A, Schwartz Richard C, Haslam Sandra Z
Abstract excerpt
Premenopausal breast cancer is associated with increased animal fat consumption among normal weight, but not overweight women (Farvid et al., 2014). Our previous findings in obesity-resistant BALB/c mice similarly showed promotion of carcinogen-induced mammary tumorigenesis by a diet high in saturated animal fat (HFD). This effect was specific to pubertal versus adult HFD. This study identifies the effects of HFD...
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