Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Amelioration of intractable epilepsy by adjunct vagus nerve stimulation therapy in a girl with a CDKL5 mutation.

Brain & development - 1 Apr 2017

Baba Shimpei, Sugawara Yuji, Moriyama Kengo, Inaji Motoki, Maehara Taketoshi, Yamamoto Toshiyuki, Morio Tomohiro

Abstract excerpt

We report the case of on an 8-year-old girl with a cyclin-dependent kinase-like 5 mutation and who underwent vagus nerve stimulation (VNS) therapy for 2years. She had developed epilepsy at the age of 6months and had severe developmental delays. Initially, she had tonic and tonic-clonic seizures; however, around the age of 5years, she also developed epileptic spasms. These seizures were never completely controlled...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Anticonvulsants
Share to Brain

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Combined Modality Therapy

Share to Drug Resistant Epilepsy

Share to Mutation

Share to Protein Serine-Threonine Kinases

Share to Treatment Outcome

Source

Identifiers

PMID: 27823948
DOI: 10.1016/j.braindev.2016.10.007

Genes

CDKL5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Amelioration of intractable epilepsy by adjunct vagus nerve stimulation therapy in a girl with a CDKL5 mutation.PMID 27823948Read ↗

Historic, clinical, and prognostic features of epileptic encephalopathies caused by CDKL5 mutations.Semantic proximity Read ↗

CDKL5 gene-related epileptic encephalopathy: electroclinical findings in the first year of life.Semantic proximity Read ↗

Vagus Nerve Stimulation in Intractable Epilepsy Associated With SCN1A Gene Abnormalities.Semantic proximity Read ↗

Deficiency of cyclin-dependent kinase-like 5 causes spontaneous epileptic seizures in neonatal miceSemantic proximity Read ↗

Seizures and electroencephalographic findings in CDKL5 mutations: case report and review.Semantic proximity Read ↗

CDKL5 mutations as a cause of severe epilepsy in infancy: clinical and electroencephalographic long-term course in 4 patients.Semantic proximity Read ↗

Retrospective evaluation of low long-term efficacy of antiepileptic drugs and ketogenic diet in 39 patients with CDKL5-related epilepsy.Semantic proximity Read ↗

Myoclonic encephalopathy in the CDKL5 gene mutation.Semantic proximity Read ↗

What we know and would like to know about CDKL5 and its involvement in epileptic encephalopathy.Semantic proximity Read ↗

CDKL5 variant in a boy with infantile epileptic encephalopathy: case report.Semantic proximity Read ↗

Clinical phenotype of 5 females with a CDKL5 mutation.Semantic proximity Read ↗

Immunotherapy for GRIN2A and GRIN2D-related epileptic encephalopathy.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.