Article
A Novel Murine Model of Parvovirus Associated Dilated Cardiomyopathy Induced by Immunization with VP1-Unique Region of Parvovirus B19.
BioMed research international - 1 Jan 2016
Bogomolovas Julijus, Šimoliūnas Egidijus, Rinkūnaitė Ieva, Smalinskaitė Luka, Podkopajev Andrej, Bironaitė Daiva, Weis Cleo-Aron, Marx Alexander, Bukelskienė Virginija, Gretz Norbert, Grabauskienė Virginija, Labeit Dittmar, Labeit Siegfried
Abstract excerpt
Background. Parvovirus B19 (B19V) is a common finding in endomyocardial biopsy specimens from myocarditis and dilated cardiomyopathy patients. However, current understanding of how B19V is contributing to cardiac damage is rather limited due to the lack of appropriate mice models. In this work we demonstrate that immunization of BALB/c mice with the major immunogenic determinant of B19V located in the unique...
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