Article
Visceral Adipose MicroRNA 223 Is Upregulated in Human and Murine Obesity and Modulates the Inflammatory Phenotype of Macrophages.
PloS one - 1 Jan 2016
Deiuliis Jeffrey A, Syed Rafay, Duggineni Dheeraj, Rutsky Jessica, Rengasamy Palanivel, Zhang Jie, Huang Kun, Needleman Bradley, Mikami Dean, Perry Kyle, Hazey Jeffrey, Rajagopalan Sanjay
Abstract excerpt
Obesity in humans and mice is typified by an activated macrophage phenotype in the visceral adipose tissue (VAT) leading to increased macrophage-mediated inflammation. microRNAs (miRNAs) play an important role in regulating inflammatory pathways in macrophages, and in this study we compared miRNA expression in the VAT of insulin resistant morbidly obese humans to a non-obese cohort with normal glucose tolerance....
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