Article
Nonstructural Protein NSs of Schmallenberg Virus Is Targeted to the Nucleolus and Induces Nucleolar Disorganization.
Journal of virology - 1 Jan 2017
Gouzil Julie, Fablet Aurore, Lara Estelle, Caignard Grégory, Cochet Marielle, Kundlacz Cindy, Palmarini Massimo, Varela Mariana, Breard Emmanuel, Sailleau Corinne, Viarouge Cyril, Coulpier Muriel, Zientara Stéphan, Vitour Damien
Abstract excerpt
Schmallenberg virus (SBV) was discovered in Germany in late 2011 and then spread rapidly to many European countries. SBV is an orthobunyavirus that causes abortion and congenital abnormalities in ruminants. A virus-encoded nonstructural protein, termed NSs, is a major virulence factor of SBV, and it is known to promote the degradation of Rpb1, a subunit of the RNA polymerase II (Pol II) complex, and therefore...
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