Article
Performance of multiplicom's BRCA MASTR Dx kit on the detection of BRCA1 and BRCA2 mutations in fresh frozen ovarian and breast tumor samples.
Oncotarget - 6 Dec 2016
Badoer Cindy, Garrec Céline, Goossens Dirk, Ellison Gillian, Mills John, Dzial Mélina, El Housni Hakim, Berwouts Sarah, Concolino Paola, Guibert-Le Guevellou Virginie, Delnatte Capucine, Del Favero Jurgen, Capoluongo Ettore, Bézieau Stéphane
Abstract excerpt
Next-generation sequencing (NGS) has enabled new approaches for detection of mutations in the BRCA1 and BRCA2 genes responsible for hereditary breast and ovarian cancer (HBOC). The search for germline mutations in the BRCA1 and BRCA2 genes is of importance with respect to oncogenetic and surgical (bilateral mastectomy, ovariectomy) counselling. Testing tumor material for BRCA mutations is of increasing importance...
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